Platelet-derived growth factor receptor alpha-driven pediatric glioblastoma model with p53 null background
Summary:
Analysis of high-grade gliomas (HGG) driven by intracranial implantation of p53-null astrocytes expressing any of 6 different mutant forms of platelet derived growth factor receptor alpha (Pdgfrα) found in pediatric HGGs. Results provide insight into the role of PDGFRα mutations in pediatric HGGs.
Paugh BS, Zhu X, Qu C, Endersby R et al. Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. Cancer Res 2013 Oct 15;73(20):6219-29. PMID: 23970477
