Analysis of CD3-positive T cells isolated from 10 systemic lupus erythematosus (SLE) patients and 9 healthy controls. SLE is an autoimmune disease characterized by T cell dysfunction. Results provide insight into molecular mechanisms underlying SLE in T cells.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Fernandez DR, Telarico T, Bonilla E, Li Q et al. Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J Immunol 2009 Feb 15;182(4):2063-73. PMID: 19201859
