Spleen response to acute LCMV-Armstrong and persistent LCMV-Clone13 infections: time course
Summary:
Analysis of spleen infected with 2 strains of lymphocytic choriomeningitis virus. LCMV-Arm induces T-cell response that resolves infection within 10 days; LCMV-Cl13 induces persistent infection via immunosuppression. Results provide insight into molecular basis of virus-induced immunosuppression.
Wilson EB, Yamada DH, Elsaesser H, Herskovitz J et al. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science 2013 Apr 12;340(6129):202-7. PMID: 23580528