G-protein-coupled receptor kinase 2 inhibition effect on HEK cells in vitro and in vivo
Summary:
Analysis of HEK cells expressing dominant-negative GRK2-K220R. HEK cells were cultured, or expanded in NOD.Scid mice, or re-cultured after NOD.Scid expansion. GRK2-K220R enhances growth of NOD.Scid HEK cells but not cultured HEK cells. Results provide insight into basis of growth control by GRK2.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Fu X, Koller S, Abd Alla J, Quitterer U. Inhibition of G-protein-coupled receptor kinase 2 (GRK2) triggers the growth-promoting mitogen-activated protein kinase (MAPK) pathway. J Biol Chem 2013 Mar 15;288(11):7738-7755. PMID: 23362259
