Pulmonary vascular microendothelial cell response to mutations in type 2 receptor for the bone morphogenetic protein signaling pathway, BMPR2
Summary:
Analysis of PMVECs cultured from triple transgenics carrying immortomouse gene, a transactivator, and either control, Bmpr2delx4+ or Bmpr2R899X mutation. Hereditary pulmonary arterial hypertension is often associated with BMPR2 mutations. Results provide insight into role of Bmpr2 in endothelium.
Majka S, Hagen M, Blackwell T, Harral J et al. Physiologic and molecular consequences of endothelial Bmpr2 mutation. Respir Res 2011 Jun 22;12:84. PMID: 21696628
