Analysis of liver endoplasmic reticulum (ER)-associated polysomes from leptin deficient (ob/ob) males after overnight fasting. The liver is critical for metabolic homeostasis. Results provide insight into molecular mechanisms underlying changes in protein metabolism caused by obesity and diabetes.
Fu S, Fan J, Blanco J, Gimenez-Cassina A et al. Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. PLoS Genet 2012 Aug;8(8):e1002902. PMID: 22927828