Fetal liver hematopoietic stem cells heterozygous for CREB binding protein
Summary:
Analysis of HSCs sorted fromCrebbp+/− day 14 fetal livers. Crebbp+/− mice inevitably develop myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) within 9 to 12 months of age. Results provide insight into the molecular mechanisms underlying deregulation of HSC in MDS/MPN.
Zimmer SN, Lemieux ME, Karia BP, Day C et al. Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm. Exp Hematol 2012 Apr;40(4):295-306.e5. PMID: 22198154