Bacterial cell wall component MDP effect on HEK293 cells expressing Crohn's disease-associated NOD2 variant L1007fsinsC receptor: time course
Summary:
Temporal analysis of HEK293 cells stably-expressing wildtype NOD2 receptor or variant NOD2L1007fsinsC and treated with muramyl dipeptide (MDP). MDP-induced NOD2 activation induces inflammatory and antibacterial factors. Results provide insight into molecular basis of NOD2-mediated immune response.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Billmann-Born S, Till A, Arlt A, Lipinski S et al. Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC. J Immunol 2011 Apr 1;186(7):4027-38. PMID: 21335489
