Effect of macrophage-specific peroxisome proliferator-activated receptor-gamma deficiency on induced inflammatory bowel disease
Summary:
Analysis of colon from macrophage PPARγ-deficient C57BL/6 mice and control littermates following dextran sulfate sodium challenge to induce colitis. Deficiency of PPARγ in macrophages worsens colitis severity. Results provide insight into molecular basis of the effects of macrophage PPARγ in IBD.
Hontecillas R, Horne WT, Climent M, Guri AJ et al. Immunoregulatory mechanisms of macrophage PPAR-γ in mice with experimental inflammatory bowel disease. Mucosal Immunol 2011 May;4(3):304-13. PMID: 21068720
