DataSet Record GDS4256: Expression Profiles Data Analysis Tools Sample Subsets
Title: Caseous tuberculosis granulomas comparison with normal lung parenchyma
Cluster AnalysisGDS4256 Cluster Image
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Summary: Analysis of caseous pulmonary tuberculosis (TB) granulomas. TB progression involves caseous granuloma development that cavitates, releasing infectious Mycobacterium tuberculosis bacilli. Results provide insight into TB etiology and pathogen-mediated dysregulation of host lipid metabolism.
Organism: Homo sapiens
Platform: GPL1352: [U133_X3P] Affymetrix Human X3P Array
Citations:
  • Kim MJ, Wainwright HC, Locketz M, Bekker LG et al. Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism. EMBO Mol Med 2010 Jul;2(7):258-74. PMID: 20597103
  • Seimon TA, Kim MJ, Blumenthal A, Koo J et al. Induction of ER stress in macrophages of tuberculosis granulomas. PLoS One 2010 Sep 15;5(9):e12772. PMID: 20856677
  • Huang L, Ye K, McGee MC, Nidetz NF et al. Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against <i>Mycobacterium tuberculosis</i> Infection. Front Immunol 2019;10:3103. PMID: 32038633
Reference Series: GSE20050 Sample count: 7
Value type: transformed count Series published: 2010/06/02