Analysis of cystic fibrosis (CF) bronchial epithelial CFBE41o- cells exposed to Pseudomonas aeruginosa PA01 biofilms. Cells overexpressing 508del-CFTR and cells rescued with wild type CFTR were examined. CFTR mutations enhance the inflammatory response in the lung to PA01 infection.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Hampton TH, Ballok AE, Bomberger JM, Rutkowski MR et al. Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells? Am J Physiol Lung Cell Mol Physiol 2012 Sep 15;303(6):L509-18. PMID: 22821996
