Simian immunodeficiency virus encephalitis model of HIV-associated dementia: hippocampus
Summary:
Analysis of hippocampus from simian immunodeficiency virus (SIV) encephalitis and control monkeys. Rhesus SIV encephalitis closely models human HIV-associated dementia (HAD) occurring in patients with advanced HIV. Results provide insight into molecular mechanisms underlying HAD cognitive deficits.
Gersten M, Alirezaei M, Marcondes MC, Flynn C et al. An integrated systems analysis implicates EGR1 downregulation in simian immunodeficiency virus encephalitis-induced neural dysfunction. J Neurosci 2009 Oct 7;29(40):12467-76. PMID: 19812322
