Analysis of differentiating E14 TG2a ESCs with cell surface expression of 5T4. The upregulation of 5T4 expression is associated with loss of pluripotency in ES cells. Results provide insight into molecular mechanisms underlying the balance between pluripotency and differentiation in ES cells.
Southgate TD, McGinn OJ, Castro FV, Rutkowski AJ et al. CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells. PLoS One 2010 Apr 1;5(4):e9982. PMID: 20376365