CD3+ T cell response to stimulation with CD3/CD28 or nitric oxide
Summary:
Analysis of healthy T cells stimulated with CD3/CD28 (a Ca2+ fluxing inducer) or NO (a key trigger of mitochondrial hyperpolarization (MHP)). Enhanced Ca2+ fluxing and MHP underlie aberrant T-cell activation in SLE. Results provide insight into the molecular basis of T cell dysfunction in lupus.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Fernandez DR, Telarico T, Bonilla E, Li Q et al. Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J Immunol 2009 Feb 15;182(4):2063-73. PMID: 19201859
