Parkinson's disease induced pluripotent stem cell model with triplication of the α-synuclein locus
Summary:
Analysis of iPSC lines derived from a PD patient with SNCA triplication and an unaffected first-degree relative. Triplication of SNCA, encoding α-synuclein, causes an aggressive form of PD. Results provide insight into the mechanistic basis of neurodegeneration caused by α-synuclein dysfunction.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Devine MJ, Ryten M, Vodicka P, Thomson AJ et al. Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus. Nat Commun 2011 Aug 23;2:440. PMID: 21863007
