Response of pancreatic and colorectal cancer cells to CD24 down-regulation by monoclonal antibody or small interfering RNA
Summary:
Analysis of HT29 and Colo357 cancer cell lines following treatment with anti-CD24 mAbs, and HT29 cells after expression of 1 or 2 shRNA vectors directed at the CD24 gene. CD24 is overexpressed in a large variety of human malignancies. Results provide insight into the role of CD4 in carcinogenesis.
GPL571:
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Citation:
Sagiv E, Starr A, Rozovski U, Khosravi R et al. Targeting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or small interfering RNA. Cancer Res 2008 Apr 15;68(8):2803-12. PMID: 18413748
