Proteasome inhibitor Bortezomib effect on MCF7 breast cancer cells
Summary:
Analysis of MCF7 cells stimulated with bortezomib (velcade). Proteasome inhibition can regulate estrogen-induced transcription. Results provide insight into the mechanisms by which proteasome inhibition influences ERα function and may uncover improved strategies for the treatment of breast cancer.
Prenzel T, Begus-Nahrmann Y, Kramer F, Hennion M et al. Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B. Cancer Res 2011 Sep 1;71(17):5739-53. PMID: 21862633
