Estrogen receptor alpha-silenced MCF7 breast cancer cells
Summary:
Analysis of MCF7 breast cancer cells after siRNA-mediated silencing of the estrogen receptor α (ERα). The induced ERα silencing resulted in estrogen/tamoxifen resistant cells (pII). Results provide insight into molecular events underlying the endocrine drug resistant phenotype in breast cancer.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Al Saleh S, Al Mulla F, Luqmani YA. Estrogen receptor silencing induces epithelial to mesenchymal transition in human breast cancer cells. PLoS One 2011;6(6):e20610. PMID: 21713035
