Analysis of peripheral blood from Cbfb+/MYH11 and Cbfb-/- E12.5 embryos with that of their wildtype littermates. Cbfb+/MYH11 embryos had defects in both primitive and definitive hematopoiesis. Results provide insight into the mechanisms by which CBFB-MYH11 may contribute to leukemogenesis.
Hyde RK, Kamikubo Y, Anderson S, Kirby M et al. Cbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11. Blood 2010 Feb 18;115(7):1433-43. PMID: 20007544
