Time course of diabetes-induced, anti-Interferon-γ injected NOD.Scid mice: pancreatic islets
Summary:
Temporal analysis of microdissected islets of NOD.Scid mice injected with diabetogenic CD4+BDC2.5 (BDC) T cells, then injected with anti-interferon-γ monoclonal antibody which protected the mice from developing diabetes. Results provide insight into the role of INF-γ role in autoimmune diabetes.
Calderon B, Suri A, Pan XO, Mills JC et al. IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes. J Immunol 2008 Nov 15;181(10):6964-74. PMID: 18981116
