Analysis of glomeruli isolated from kidneys of 8 week old, diabetic OVE26 males. The OVE26 type 1 mouse is a model of progressive glomerulosclerosis and decline of renal function. Results provide insight into the pathogenic mechanisms linked to diabetic nephropathy in the OVE26 model.
Reiniger N, Lau K, McCalla D, Eby B et al. Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse. Diabetes 2010 Aug;59(8):2043-54. PMID: 20627935
