Embryonic fibroblast response to forced expression of select transcription factors
Summary:
Analysis of motor neurons harvested from Hb9::GFP-transgenic E13.5 embryos, derived from Hb9 GFP ESCs, and made from embryonic fibroblasts by overexpression of 10 transcription factors (TF). Results provide insight into molecular basis of TF-mediated conversion of fibroblasts into motor neurons.
Son EY, Ichida JK, Wainger BJ, Toma JS et al. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell 2011 Sep 2;9(3):205-18. PMID: 21852222
