Analysis of FIH-null large T antigen-immortalized murine embryonic fibroblasts (MEFs) grown under normoxic conditions. von Hippel-Lindau tumor suppressor gene (VHL)-null and VHL/FIH-null mutants were also examined. Results provide insight into the role of FIH as an essential regulator of metabolism.
Zhang N, Fu Z, Linke S, Chicher J et al. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab 2010 May 5;11(5):364-78. PMID: 20399150