Analysis of kidneys from animals deficient for Claudin16. Mutations in Caludin16 are associated with renal Ca2+ and Mg2+ wasting, nephrocalcinosis and progressive renal insufficiency in humans. Results provide insight into the role of Caludin16 in Ca2+ and Mg2+ homeostasis.
Will C, Breiderhoff T, Thumfart J, Stuiver M et al. Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am J Physiol Renal Physiol 2010 May;298(5):F1152-61. PMID: 20147368