Pancreatic islet response to glucose in vitro: dose response
Summary:
Analysis of pancreatic islets cultured for 18 hours in 2, 5, 10, or 30 mM glucose. Culture in 2 to 10 mM glucose improves beta cell survival and function, while concentrations above 10 mM are deleterious. Results provide insight into the molecular basis of this sensitivity to glucose concentrations.
GPL1355:
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Citation:
Bensellam M, Van Lommel L, Overbergh L, Schuit FC et al. Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations. Diabetologia 2009 Mar;52(3):463-76. PMID: 19165461
