Analysis of Barrett's esophagus (BE), normal esophageal, and small intestinal biopsies. In BE, normal esophageal squamous epithelium transdifferentiates into simple columnar epithelium resembling that of small intestine. Results provide insight into the molecular basis of this transdifferentiation.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Stairs DB, Nakagawa H, Klein-Szanto A, Mitchell SD et al. Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus. PLoS One 2008;3(10):e3534. PMID: 18953412
