B-precursor acute lymphoblastic leukemia tumors sensitive and resistant to ionizing radiation
Summary:
Analysis of B-precursor acute lymphoblastic (ALL) tumor cells exposed to ionizing radiation (IR) to induce DNA damage in vitro. Half of the tumors are sensitive to IR induced apoptosis. Results provide insight into the molecular basis of the differences in response of B-precursor ALL to IR.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Marston E, Weston V, Jesson J, Maina E et al. Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response. Blood 2009 Jan 1;113(1):117-26. PMID: 18941120
