Multifunctional protein 2 deficiency effect on the liver
Summary:
Analysis of livers of 2 day old mutants lacking multifunctional protein 2 (Mfp2), an enzyme of the peroxisomal beta-oxidation pathway. Mfp2 deficiency results in extensive metabolic and pathological abnormalities starting in the postnatal period and leads to death by the age of 6 months.
Martens K, Ver Loren van Themaat E, van Batenburg MF, Heinäniemi M et al. Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice. Biochim Biophys Acta 2008 Nov-Dec;1781(11-12):694-702. PMID: 18773970