Frontotemporal lobar degeneration with ubiquitinated inclusions and progranulin mutations: various brain regions
Summary:
Analysis of various brain regions of patients who suffered from frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U). Presence of progranulin (GRN) mutations determined. GRN mutations are associated with FTLD-U. Results identify expression signatures for GRN subtypes of FTLD-U.
GPL571:
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Citation:
Chen-Plotkin AS, Geser F, Plotkin JB, Clark CM et al. Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration. Hum Mol Genet 2008 May 15;17(10):1349-62. PMID: 18223198
