Analysis of embryonic (E12.5) kidneys with beta-catenin deficiency targeted to the ureteric bud cell lineage. Inactivation of beta-catenin leads to abnormal ureteric branching and causes renal aplasia or dysplasia. Results provide insight into the role of beta-catenin during ureteric morphogenesis.
Bridgewater D, Cox B, Cain J, Lau A et al. Canonical WNT/beta-catenin signaling is required for ureteric branching. Dev Biol 2008 May 1;317(1):83-94. PMID: 18358465
