Madin-Darby canine kidney type II cell line response to hepatocyte growth factor
Summary:
Analysis of MDCK cells exposed to hepatocyte growth factor (HGF), a MAPK pathway activator. MDCK cells also exposed to HGF plus MAPK inhibitors. Epithelial organs such as kidney develop via tubulogenesis, a process induced by MAPK activation. Results provide insight into HGF-induced tubulogenesis.
Hellman NE, Spector J, Robinson J, Zuo X et al. Matrix metalloproteinase 13 (MMP13) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1), regulated by the MAPK pathway, are both necessary for Madin-Darby canine kidney tubulogenesis. J Biol Chem 2008 Feb 15;283(7):4272-82. PMID: 18039671
