Topoisomerase IIbeta deficiency effect on the developing embryonic brain
Summary:
Anlaysis of brains from topoisomerase IIbeta (TopIIbeta) deficient embryos at various ages up to embryonic day 18.5. TopIIbeta null animals exhibit a perinatal death phenotype. Results provide insight into the role of TopIIbeta at the late stages of neuronal differentiation.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Lyu YL, Lin CP, Azarova AM, Cai L et al. Role of topoisomerase IIbeta in the expression of developmentally regulated genes. Mol Cell Biol 2006 Nov;26(21):7929-41. PMID: 16923961
