Monocyte differentiation to macrophage and subsequent polarization (HG-U133B)
Summary:
Analysis of monocytes (MCs) treated with M-CSF to induce differentiation into macrophages (MPs), and mature MPs treated with either IFN-gamma and LPS or IL-4 to induce polarization to M1 or M2 cells, respectively. Results provide insight into MC to MP differentiation and polarized activation.
GPL97:
[HG-U133B] Affymetrix Human Genome U133B Array
Citations:
Martinez FO, Gordon S, Locati M, Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol 2006 Nov 15;177(10):7303-11. PMID: 17082649
Solinas G, Schiarea S, Liguori M, Fabbri M et al. Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility. J Immunol 2010 Jul 1;185(1):642-52. PMID: 20530259
