PGC-1alpha transcriptional coactivator null mutation effect on the brain striatum
Summary:
Analysis of brain striatum of PGC-1alpha transcriptional coactivator null mutants. PGC-1alpha regulates several metabolic processes. Altered energy metabolism is implicated in Huntington's disease (HD). Results provide insight into the role of PGC-1alpha in HD pathogenesis.
Cui L, Jeong H, Borovecki F, Parkhurst CN et al. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell 2006 Oct 6;127(1):59-69. PMID: 17018277
