DataSet Record GDS2303: Expression Profiles Data Analysis Tools Sample Subsets
Title: ATP binding cassette transporter A1 overexpression effect on LDL receptor-deficient livers
Cluster AnalysisGDS2303 Cluster Image
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Summary: Analysis of livers of LDL receptor (LDLr) knockout (KO) mutants overexpressing ATP binding cassette transporter A1 (ABCA1), responsible for cellular lipid efflux. LDLr KO is a model of hypercholesterolemia. Results provide insight into the role of ABCA1 in cholesterol metabolism and atherosclerosis.
Organism: Mus musculus
Platform: GPL339: [MOE430A] Affymetrix Mouse Expression 430A Array
Citation:
  • Joyce CW, Wagner EM, Basso F, Amar MJ et al. ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis. J Biol Chem 2006 Nov 3;281(44):33053-65. PMID: 16928680
Reference Series: GSE5496 Sample count: 8
Value type: count Series published: 2006/08/10