Nodal, Mixer, and Sox17 inactivation effect on gastrula stage embryo
Summary:
Analysis of stage 11 embryos inactivated for Nodal signaling, or depleted of Mixer or Sox17 proteins. Microdissected animal caps and vegetal and equatorial regions of stage 11 embryos also examined. Nodal, Mixer, and Sox17 are key proteins of a pathway controlling endoderm formation.
Sinner D, Kirilenko P, Rankin S, Wei E et al. Global analysis of the transcriptional network controlling Xenopus endoderm formation. Development 2006 May;133(10):1955-66. PMID: 16651540