Hepatocyte nuclear factor 4 alpha knockout effect on the embryonic liver
Summary:
Analysis of embryonic day 18.5 livers lacking hepatocyte nuclear factor 4 alpha (HNF4alpha). Cre/lox system used to knock out Hnf4a in liver. HNF4alpha is a nuclear hormone transcription factor. Results provide insight into the role of HNF4alpha in hepatogenesis.
Battle MA, Konopka G, Parviz F, Gaggl AL et al. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc Natl Acad Sci U S A 2006 May 30;103(22):8419-24. PMID: 16714383
