Camptothecin effect on renal epithelial cell line and HIV transduction
Summary:
Analysis of renal epithelial cell line 293T following treatment with 2 uM camptothecin, which boosts transduction of cells by HIV. Camptothecin induces DNA damage and arrests cell cycle at G2/M. Results provide insight into the mechanisms underlying HIV transduction boost induced by camptothecin.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Groschel B, Bushman F. Cell cycle arrest in G2/M promotes early steps of infection by human immunodeficiency virus. J Virol 2005 May;79(9):5695-704. PMID: 15827184
