Examination of chronic intermittent hypoxia (CIH) effect on liver gene expression in leptin deficient (ob/ob) mice. CIH in the presence of pre-existent obesity may cause an increase in gene expression of enzymes of lipid biosynthesis. CIH is a component of obstructive sleep apnea (OSA).
Li J, Grigoryev DN, Ye SQ, Thorne L et al. Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice. J Appl Physiol (1985) 2005 Nov;99(5):1643-8. PMID: 16037401