Macrophage response to lipopolysaccharide: time course
Summary:
Expression profiling of RAW264.7 macrophage cells exposed to 100 ng/ml of lipopolysaccharide (LPS) for 2 and 12 hours. Macrophages secrete proinflammatory cytokines in response to LPS. Results provide insight into trafficking and secretion of cytokines in macrophages.
Murray RZ, Wylie FG, Khromykh T, Hume DA et al. Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha. J Biol Chem 2005 Mar 18;280(11):10478-83. PMID: 15640147
