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Search results for: 1-Oxa-3,9-diazaspiro[5.5]undecan-2-one

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Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones

RD Clark et al. J Med Chem (1983)
Forty-one 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones were prepared for antihypertensive screening in the spontaneously hypertensive rat (SHR). For the 9-(2-indol-3-ylethyl) series, the parent compound, 9-(2-indol-3-ylethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one (21), was the most potent antihypertensive agent. Substitution of lower alkyl groups on …

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