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COG definitions	Organims	Proteins	Median Protein Length	Genes
215	2,296	469,340	232.0	182

Organism	Protein	COG	Cat	Annotation
2256	2412	COG0085	K	DNA-directed RNA polymerase, beta subunit/140 kD subunit
2250	2521	COG0086	K	DNA-directed RNA polymerase, beta' subunit/160 kD subunit
2251	2322	COG0195	K	Transcription antitermination factor NusA, contains S1 and KH domains
2258	2368	COG0202	K	DNA-directed RNA polymerase, alpha subunit/40 kD subunit
2051	2219	COG0217	J K	Transcriptional and/or translational regulatory protein YebC/TACO1
2268	2839	COG0250	K	Transcription termination/antitermination protein NusG
869	1153	COG0271	K T	DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation
1992	3169	COG0317	K T	(p)ppGpp synthase/hydrolase, HD superfamily
115	124	COG0454	K R	N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2)
1491	3044	COG0553	K L	Superfamily II DNA or RNA helicase, SNF2 family
1844	2255	COG0557	K	Exoribonuclease R
2086	4965	COG0568	K	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)
2068	2168	COG0571	K	dsRNA-specific ribonuclease
1902	34485	COG0583	K	DNA-binding transcriptional regulator, LysR family
2064	10977	COG0640	K	DNA-binding transcriptional regulator, ArsR family
1807	1918	COG0718	K	DNA-binding nucleoid-associated protein YbaB/EfbC
2126	31286	COG0745	K T	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain
2182	2501	COG0750	K O	Membrane-associated protease RseP, regulator of RpoE activity
2078	2921	COG0781	K	Transcription antitermination protein NusB
1985	3481	COG0782	K	Transcription elongation factor, GreA/GreB family
1906	9983	COG0789	K	DNA-binding transcriptional regulator, MerR family
1983	2075	COG0816	J K L	YqgF/RuvX protein, pre-16S rRNA maturation RNase/Holliday junction resolvase/anti-termination factor
627	899	COG0864	K	Metal-responsive transcriptional regulator, contains CopG/Arc/MetJ DNA-binding domain
1435	2810	COG1061	K L	Superfamily II DNA or RNA helicase
192	192	COG1095	K	DNA-directed RNA polymerase, subunit E'/Rpb7
1818	1930	COG1158	K	Transcription termination factor Rho
1484	4772	COG1167	K E	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain
1096	1806	COG1191	K	DNA-directed RNA polymerase specialized sigma subunit
1975	2011	COG1197	K L	Transcription-repair coupling factor (superfamily II helicase)
209	343	COG1221	K T	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
42	42	COG1224	K	DNA helicase TIP49, TBP-interacting protein
1871	5933	COG1278	K	Cold shock protein, CspA family
199	202	COG1308	K	Transcription factor homologous to NACalpha-BTF3
2048	31532	COG1309	K	DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA
59	68	COG1318	K	Predicted transcriptional regulator
1283	2101	COG1321	K	Mn-dependent transcriptional regulator MntR, DtxR family
1669	1710	COG1327	K	Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains
834	911	COG1329	K	RNA polymerase-interacting regulator, CarD/CdnL/TRCF family
1254	4012	COG1349	K G	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family
82	93	COG1356	K	Transcriptional regulator
394	1051	COG1378	K	Sugar-specific transcriptional regulator TrmB
1638	1752	COG1386	K	Chromosome segregation and condensation protein ScpB
200	206	COG1395	K	Predicted transcriptional regulator
1935	14929	COG1396	K	Transcriptional regulator, contains XRE-family HTH domain
191	891	COG1405	K	Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB
1217	6204	COG1414	K	DNA-binding transcriptional regulator, IclR family
1417	1425	COG1420	K	Transcriptional regulator of heat shock response
729	820	COG1438	K	Arginine repressor
186	188	COG1460	K	DNA-directed RNA polymerase, subunit F
1296	3280	COG1476	K	DNA-binding transcriptional regulator, XRE-family HTH domain
647	649	COG1481	K	DNA-binding transcriptional regulator WhiA, involved in cell division
117	122	COG1497	K	Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain
1360	1466	COG1508	K	DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
571	771	COG1510	K	DNA-binding transcriptional regulator GbsR, MarR family
1782	9472	COG1522	K	DNA-binding transcriptional regulator, Lrp family
115	179	COG1581	K	DNA/RNA-binding protein AlbA/Ssh10b
206	347	COG1594	K	DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS
1866	22302	COG1595	K	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family
1414	13436	COG1609	K	DNA-binding transcriptional regulator, LacI/PurR family
191	191	COG1644	K	DNA-directed RNA polymerase, subunit N (RpoN/RPB10)
835	876	COG1654	K	Biotin operon repressor
169	172	COG1675	K	Transcription initiation factor IIE, alpha subunit
1151	1179	COG1678	K	Putative transcriptional regulator, AlgH/UPF0301 family
66	93	COG1693	K	Repressor of nif and glnA expression
1413	5042	COG1695	K	DNA-binding transcriptional regulator, PadR family
183	186	COG1709	K	Predicted transcriptional regulator,contains XRE-type HTH domain
950	2074	COG1725	K	DNA-binding transcriptional regulator YhcF, GntR family
1490	4948	COG1733	K	DNA-binding transcriptional regulator, HxlR family
1588	2654	COG1734	K	RNA polymerase-binding transcription factor DksA
1003	3100	COG1737	K	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains
1798	1809	COG1758	K	DNA-directed RNA polymerase, subunit K/omega
189	190	COG1761	K	DNA-directed RNA polymerase, subunit L/RPAC2
243	364	COG1777	K	Predicted transcriptional regulator, ArsR family
1273	7163	COG1802	K	DNA-binding transcriptional regulator, GntR family
255	284	COG1827	K H	Transcriptional regulator of NAD metabolism, contains HTH and 3H domains
1995	16130	COG1846	K	DNA-binding transcriptional regulator, MarR family
1095	1744	COG1937	K	DNA-binding transcriptional regulator, FrmR family
1738	6428	COG1940	K G	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain
230	283	COG1954	K	Glycerol-3-phosphate responsive antiterminator (mRNA-binding)
186	319	COG1958	K	Small nuclear ribonucleoprotein (snRNP) homolog
1789	4399	COG1959	K	DNA-binding transcriptional regulator, IscR family
1752	2751	COG1974	K T	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)
911	1406	COG1983	K T	Phage shock protein PspC (stress-responsive transcriptional regulator)
312	353	COG1996	K	DNA-directed RNA polymerase, subunit RPC12/RpoP, contains C4-type Zn-finger
577	1017	COG2002	K V	Bifunctional DNA-binding transcriptional regulator of stationary/sporulation/toxin gene expression and antitoxin component of the YhaV-PrlF toxin-antitoxin module
759	959	COG2005	K	DNA-binding transcriptional regulator ModE (molybdenum-dependent)
190	191	COG2012	K	DNA-directed RNA polymerase, subunit H, RpoH/RPB5
211	216	COG2093	K	RNA polymerase subunit RPABC4/transcription elongation factor Spt4
188	315	COG2101	K	TATA-box binding protein (TBP), component of TFIID and TFIIIB
1332	1348	COG2183	K	Transcriptional accessory protein Tex/SPT6
1177	4387	COG2186	K	DNA-binding transcriptional regulator, FadR family
1320	4744	COG2188	K	DNA-binding transcriptional regulator, GntR family
1858	17938	COG2197	K T	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains
1712	20612	COG2207	K	AraC-type DNA-binding domain and AraC-containing proteins
1025	3737	COG2208	K T	Phosphoserine phosphatase RsbU, regulator of sigma subunit
217	264	COG2214	K	Curved DNA-binding protein CbpA, contains a DnaJ-like domain
752	871	COG2315	K	Predicted DNA-binding protein with double-wing structural motif, MmcQ/YjbR family
648	742	COG2344	K	NADH/NAD ratio-sensing transcriptional regulator Rex
627	975	COG2345	K	Predicted transcriptional regulator, ArsR family
1465	3648	COG2378	K	Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains
657	1231	COG2390	K	DNA-binding transcriptional regulator LsrR, DeoR family
508	1714	COG2508	K	DNA-binding transcriptional regulator, PucR/PutR family
184	277	COG2522	K	Predicted transcriptional regulator, contains HTH domain
1086	1955	COG2524	K	Predicted transcriptional regulator, contains C-terminal CBS domains
213	239	COG2732	K	Barstar, RNAse (barnase) inhibitor
391	393	COG2739	K	Predicted DNA-binding protein YlxM, UPF0122 family
523	541	COG2747	K N	Negative regulator of flagellin synthesis (anti-sigma28 factor)
341	536	COG2771	K	DNA-binding transcriptional regulator, CsgD family
752	1506	COG2865	K	Predicted transcriptional regulator, contains HTH domain
448	461	COG2901	K	DNA-binding protein Fis (factor for inversion stimulation)
618	1315	COG2909	K	ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT
668	1127	COG2944	K	DNA-binding transcriptional regulator YiaG, XRE-type HTH domain
347	464	COG2964	K	Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains
138	139	COG2973	K	Trp operon repressor
128	128	COG3060	K E	Transcriptional regulator MetJ (met regulon)
455	482	COG3070	K	Transcriptional regulator of competence genes, TfoX/Sxy family
170	172	COG3160	K	Regulator of sigma D
1182	2362	COG3177	K	Fic family protein
291	613	COG3226	K	DNA-binding transcriptional regulator YbjK
1066	3985	COG3279	K T	DNA-binding response regulator, LytR/AlgR family
156	167	COG3283	K E	Transcriptional regulator TyrR of aromatic amino acids metabolism
547	940	COG3284	K	Transcriptional regulator DhaR of acetoin/glycerol metabolism
242	421	COG3289	K	Stand-alone LytTR domain, transcriptional regulator
903	1682	COG3311	K X	DNA-binding transcriptional regulator AlpA
319	443	COG3327	K	DNA-binding transcriptional regulator PaaX (phenylacetic acid degradation)
201	201	COG3343	K	DNA-directed RNA polymerase, delta subunit
177	430	COG3355	K N	Transcriptional regulator of archaellar biosynthesis and archaeal biofilm formation AfbR
134	136	COG3357	K	Predicted transcriptional regulator, contains HTH and Zn-ribbon domains
16	21	COG3373	K N	Transcriptional regulator of archaellum operon
105	132	COG3388	K	Predicted transcriptional regulator
115	315	COG3398	K	Predicted transcriptional regulator, contains two HTH domains
142	282	COG3423	K	Predicted transcriptional regulator, lambda repressor-like DNA-binding domain
79	254	COG3432	K	Predicted transcriptional regulator
797	1788	COG3604	K T	FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains
613	1176	COG3609	K	Transcriptional regulator, contains Arc/MetJ-type RHH (ribbon-helix-helix) DNA-binding domain
1126	1747	COG3620	K	Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair)
487	1970	COG3629	K	DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain
816	1384	COG3655	K	DNA-binding transcriptional regulator, XRE family
815	1741	COG3682	K	Transcriptional regulator, CopY/TcrY family
848	905	COG3695	K	Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain
1234	5588	COG3706	K T	Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain
868	1390	COG3707	K T	Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains
574	958	COG3708	K	Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain
389	1114	COG3710	K	DNA-binding winged helix-turn-helix (wHTH) domain
379	1461	COG3711	K	Transcriptional antiterminator
83	92	COG3722	K	DNA-binding transcriptional regulator, MltR family
149	230	COG3801	K	Predicted DNA-binding protein, MmcQ/YjbR superfamily
291	291	COG3820	K	Cell cycle regulator TrcR, DUF1013 family
837	2918	COG3829	K T	RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains
216	337	COG3831	K	WGR domain, predicted DNA-binding domain in MolR
485	862	COG3835	K T	Sugar diacid utilization regulator CdaR
204	227	COG3877	K	Predicted DNA-binding transcriptional regulator with XRE-family HTH domain, DUF2089 family
27	28	COG3888	K	Predicted transcriptional regulator
162	194	COG3901	K	Transcriptional regulator NosR of nitric oxide reductase
266	359	COG3905	K	Predicted transcriptional regulator, contains ribbon-helix-helix (RHH_1) domain
121	236	COG3933	K	Transcriptional regulatory protein LevR, contains PRD, AAA+ and EIIA domains
185	255	COG3947	K T	Two-component response regulator, SAPR family, consists of REC, wHTH and BTAD domains
39	40	COG4008	K	Predicted metal-binding transcription factor, methanogenesis marker domain 9
490	582	COG4109	K	Predicted transcriptional regulator containing CBS domains
237	309	COG4189	K	Predicted transcriptional regulator, ArsR family
189	317	COG4190	K	Predicted transcriptional regulator, contains HTH domain
115	142	COG4197	K	DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily
227	227	COG4255	K	Regulator of pathogenicity factor RpfE
337	365	COG4256	K H	RNA-binding regulator of hemin uptake HemP/HmuP
51	55	COG4344	K	Predicted transciptional regulator, contains HTH domain
270	270	COG4463	K	Transcriptional regulator CtsR
255	273	COG4465	K	GTP-sensing pleiotropic transcriptional regulator CodY
103	169	COG4512	K T	Accessory gene regulator protein AgrB
123	199	COG4533	K	DNA-binding transcriptional regulator SgrR of sgrS sRNA, contains a MarR-type HTH domain and a periplasmic-type solute-binding domain
511	800	COG4565	K T	DNA-binding response regulator DpiB of citrate/malate metabolism
553	1539	COG4566	K T	DNA-binding response regulator, FixJ family, consists of REC and HTH domains
494	559	COG4567	K T	DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains
136	138	COG4568	K	Transcriptional antiterminator Rof (Rho-off)
162	179	COG4578	K	DNA-binding transcriptional regulator of glucitol operon
128	133	COG4650	K T	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain
46	77	COG4738	K	Predicted transcriptional regulator
136	601	COG4742	K N	Transcriptional regulator of archaellar expression ArnR
872	2493	COG4753	K T	Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains
131	131	COG4776	K	Exoribonuclease II
40	42	COG4800	K	Predicted transcriptional regulator with an HTH domain
91	96	COG4815	K	DNA/RNA-binding protein MepB
43	43	COG4860	K	Predicted DNA-binding transcriptional regulator, ArsR family
208	273	COG4862	K T N	Negative regulator MecA of genetic competence, sporulation and motility
55	69	COG4871	K	Metal-binding trascriptional regulator, contains Fe-S cluster and ArsR family DNA binding domain
42	42	COG4888	K	Transcription elongation factor Elf1, contains Zn-ribbon domain
83	132	COG4903	K	Competence transcription factor ComK
128	135	COG4933	K	Predicted transcriptional regulator, contains an HTH and PUA-like domains
481	1071	COG4941	K	Predicted RNA polymerase sigma factor, contains C-terminal TPR domain
251	535	COG4957	K	Predicted transcriptional regulator
1202	4311	COG4977	K	Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain
16	18	COG5108	K	Mitochondrial DNA-directed RNA polymerase
4	4	COG5164	K	Transcription elongation factor SPT5
23	24	COG5190	K	TFIIF-interacting CTD phosphatase, includes NLI-interacting factor
111	146	COG5304	K	Predicted DNA binding protein, CopG/RHH family
271	317	COG5352	K	Transcription factor interacting with sigma70
90	129	COG5419	K	Hexameric transcriptional regulator RovC, contains DUF2285 domain
188	209	COG5450	K	Transcription regulator of the Arc/MetJ class
129	129	COG5503	K V	DNA-dependent RNA polymerase auxiliary subunit epsilon
100	136	COG5566	K X	Transcriptional regulator, middle operon regulator (Mor) family
21	23	COG5625	K	Predicted DNA-binding transcriptional regulator, contains HTH domain
123	132	COG5631	K	Predicted transcription regulator, contains HTH domain, MarR family
534	743	COG5662	K	Transmembrane transcriptional regulator RsiW (anti-sigma-W factor)
12	12	COG5665	K	CCR4-NOT transcriptional regulation complex, NOT5 subunit
234	234	COG5811	K D	Sporulation sigma factor SigE (mother cell-specific, SpoIIGB)
224	225	COG5812	K D	Sporulation sigma factor SigF (forespore-specific, SpoIIAC)
228	233	COG5813	K D	Sporulation sigma factor SigG (forespore-specific, SpoIIIG)
221	242	COG5814	K D	Sporulation sigma factor SigK (mother cell-specific, SpoIIIC/SpoIVCB)
233	233	COG5818	K D O	Stage II sporulation protein SpoIIGA (protease, processing of pro-sigma-E to active sigma-E)
227	236	COG5830	K D	Stage III sporulation protein SpoIIID, transcriptional regulator of sigma-E- and sigma-K-dependent genes
266	600	COG5845	K D	Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression
98	191	COG5850	K D	Prespore-specific transcriptional regulator RsfA
110	110	COG5865	K D	Forespore-specific anti-sigma-G factor CsfB/Gin
40	40	COG5870	K D	Uncharacterized sporulation protein YbaK, contains DUF2521 domain (not related to E. coli deacylase YbaK, COG2606)
966	2208	COG5905	K D	Spore transcriptional regulator GerE (stand-alone HTH domain)
59	88	COG6084	K N	Regulator of haloarchaeal motility, adhesion and cell morphology