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COGs stand for Clusters of Orthologous Genes. The database was initially created in 1997 (Tatusov et al., PMID: 9381173) followed by several updates, most recently in 2021 (Galperin et al., PMID: 33167031). The current update includes genomes from 2,103 bacterial and 193 archaeal species, of which 2,232 represent complete genomes in RefSeq and 64 are at the “Chromosome” level. The new features include updated COG annotations with corresponding references and PDB links, where available, and >100 new COGs for proteins involved in protein secretion pathways and those with unknown functions.

Search by:
  COG Definition (COG0105 or just the number 105)
  Any word in the COG name (polymerase)
  Taxonomic Category (Mollicutes)
  Organism name (Aciduliprofundum_boonei_T469)
  Pathway (Arginine biosynthesis)
  Assembly (GCA_000091165.1)
  Protein name: (prot:WP_011012300.1)
  Gene Tag: (gene_tag:Haur_1857)

Statistics

COGs Genomic loci Taxonomic
Categories
Organims Protein IDs COG symbols
4,981 5,994,451 42 2,296 5,628,142 3,986