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1964 1
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Page 1
Hypertriglyceridaemia: an update.
Wierzbicki AS, Kim EJ, Esan O, Ramachandran R. Wierzbicki AS, et al. J Clin Pathol. 2022 Dec;75(12):798-806. doi: 10.1136/jclinpath-2021-207719. Epub 2022 Jun 16. J Clin Pathol. 2022. PMID: 35710321 Review.
Many elevations of TGs are secondary to other causes, but primary hypertriglyceridaemia syndromes need to be identified. The genetic causes of hypertriglyceridaemia range from familial combined hyperlipidaemia through the autosomal recessive remnant hyperlipidaemia (relate …
Many elevations of TGs are secondary to other causes, but primary hypertriglyceridaemia syndromes need to be identified. The genetic causes …
Familial Chylomicronemia Syndrome: A Clinical Guide For Endocrinologists.
Falko JM. Falko JM. Endocr Pract. 2018 Aug;24(8):756-763. doi: 10.4158/EP-2018-0157. Endocr Pract. 2018. PMID: 30183397 Review.
OBJECTIVE: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder caused by mutations in lipoprotein lipase, resulting in accumulation of chylomicrons in plasma and hypertriglyceridemia. ...ABBREVIATIONS: apoB = apolipoprotein B; apoC-III = apolipop …
OBJECTIVE: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder caused by mutations in lipoprotein lipase, …
A Comprehensive Update on the Chylomicronemia Syndrome.
Goldberg RB, Chait A. Goldberg RB, et al. Front Endocrinol (Lausanne). 2020 Oct 23;11:593931. doi: 10.3389/fendo.2020.593931. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33193106 Free PMC article. Review.
When due to very rare monogenic mutations in the genes encoding the enzyme, lipoprotein lipase, or its regulators, APOC2, APOA5, GPIHBP1, and LMF1, it is referred to as the familial chylomicronemia syndrome. Much more frequently, the chylomicronemia syndrome results from a …
When due to very rare monogenic mutations in the genes encoding the enzyme, lipoprotein lipase, or its regulators, APOC2, APOA5, GPIHBP1, an …
Lipid-lowering agents.
Ewang-Emukowhate M, Wierzbicki AS. Ewang-Emukowhate M, et al. J Cardiovasc Pharmacol Ther. 2013 Sep;18(5):401-11. doi: 10.1177/1074248413492906. Epub 2013 Jun 27. J Cardiovasc Pharmacol Ther. 2013. PMID: 23811423 Review.
It also discusses the human trial data on some novel therapeutic agents that are being developed including those for homozygous familial hypercholesterolemia--the antisense oligonucleotide mipomersen and the microsomal transfer protein inhibitor lomitapide. ...
It also discusses the human trial data on some novel therapeutic agents that are being developed including those for homozygous familial …
Lomitapide.
[No authors listed] [No authors listed] Am J Cardiovasc Drugs. 2011 Oct 1;11(5):347-52. doi: 10.2165/11533560-000000000-00000. Am J Cardiovasc Drugs. 2011. PMID: 21846156 Review.
Aegerion Pharmaceuticals is developing lomitapide, a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treatment of both familial and primary hypercholesterolemia. Oral, once-daily lomitapide will be targeted at patients resistant to HMG-CoA …
Aegerion Pharmaceuticals is developing lomitapide, a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treat …
Genetics of Hypertriglyceridemia.
Dron JS, Hegele RA. Dron JS, et al. Front Endocrinol (Lausanne). 2020 Jul 24;11:455. doi: 10.3389/fendo.2020.00455. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 32793115 Free PMC article. Review.
At the genetic level, severely elevated triglyceride levels resulting from familial chylomicronemia syndrome (FCS) are caused by homozygous or biallelic loss-of-function variants in LPL, APOC2, APOA5, LMF1, and GPIHBP1 genes. ...
At the genetic level, severely elevated triglyceride levels resulting from familial chylomicronemia syndrome (FCS) are caused by homo …
Multifactorial chylomicronemia syndrome.
Chait A. Chait A. Curr Opin Endocrinol Diabetes Obes. 2024 Apr 1;31(2):78-83. doi: 10.1097/MED.0000000000000846. Epub 2023 Nov 23. Curr Opin Endocrinol Diabetes Obes. 2024. PMID: 37994661 Review.
RECENT FINDINGS: There have been advances in understanding the genetic underpinning of MFCS, and a better appreciation as to how to differentiate it from the much rarer familial chylomicronemia syndrome, in which there are substantial differences in the approach to their t …
RECENT FINDINGS: There have been advances in understanding the genetic underpinning of MFCS, and a better appreciation as to how to differen …
Familial chylomicronemia and multifactorial chylomicronemia.
Muñiz-Grijalvo O, Diaz-Diaz JL. Muñiz-Grijalvo O, et al. Clin Investig Arterioscler. 2021 May;33 Suppl 2:56-62. doi: 10.1016/j.arteri.2021.02.011. Clin Investig Arterioscler. 2021. PMID: 34006355 Review. English, Spanish.
Severe hypertriglyceridemia: Existing and emerging therapies.
Malick WA, Do R, Rosenson RS. Malick WA, et al. Pharmacol Ther. 2023 Nov;251:108544. doi: 10.1016/j.pharmthera.2023.108544. Epub 2023 Oct 15. Pharmacol Ther. 2023. PMID: 37848164 Review.
Although lifestyle, some medications, and certain conditions such as diabetes may lead to HTG, sHTG results from a combination of major and minor genetic defects in proteins that regulate TG lipolysis. Familial chylomicronemia syndrome (FCS) is a rare disorder caused by co …
Although lifestyle, some medications, and certain conditions such as diabetes may lead to HTG, sHTG results from a combination of major and …
65 results