Abstract
The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amanitins / chemistry*
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Amino Acid Sequence
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Animals
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Binding Sites
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Crystallography, X-Ray / methods
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Hydrogen Bonding
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Models, Molecular
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Protein Conformation
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Protein Structure, Secondary
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RNA Polymerase II / chemistry*
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Transcription, Genetic*
Substances
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Amanitins
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RNA Polymerase II