Abstract
A series of alpha-quinoxalinyl-N-substitute nitrone 1,4-dioxides has been synthesize and evaluated as antibacterial and antiprotozoal agents. Structure-activity relationships are discussed. Of the compounds tested, alpha-(3-methyl-2-quinoxalinyl)-N-methylnitrone 1,4-dioxide (2) was the most active agent in vivo against the gram-negative and the gram-positive organisms.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / therapeutic use
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Antiprotozoal Agents / chemical synthesis*
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Bacteria / drug effects
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Lethal Dose 50
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Methods
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Mice
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Protozoan Infections / drug therapy
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Quinoxalines / chemical synthesis*
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Quinoxalines / pharmacology
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Quinoxalines / toxicity
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Structure-Activity Relationship
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Turkeys
Substances
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Anti-Bacterial Agents
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Antiprotozoal Agents
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Quinoxalines