Nitrones. 7. alpha-Quinoxalinyl-N-substituted nitrone 1,4-dioxides

J Med Chem. 1977 Apr;20(4):557-60. doi: 10.1021/jm00214a019.

Abstract

A series of alpha-quinoxalinyl-N-substitute nitrone 1,4-dioxides has been synthesize and evaluated as antibacterial and antiprotozoal agents. Structure-activity relationships are discussed. Of the compounds tested, alpha-(3-methyl-2-quinoxalinyl)-N-methylnitrone 1,4-dioxide (2) was the most active agent in vivo against the gram-negative and the gram-positive organisms.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / therapeutic use
  • Antiprotozoal Agents / chemical synthesis*
  • Bacteria / drug effects
  • Lethal Dose 50
  • Methods
  • Mice
  • Protozoan Infections / drug therapy
  • Quinoxalines / chemical synthesis*
  • Quinoxalines / pharmacology
  • Quinoxalines / toxicity
  • Structure-Activity Relationship
  • Turkeys

Substances

  • Anti-Bacterial Agents
  • Antiprotozoal Agents
  • Quinoxalines