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PubMed (GeneRIF) for id: 440387
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Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis.
Biochim Biophys Acta Proteins Proteom. 2022 Sep 1;1870(9):140831. doi: 10.1016/j.bbapap.2022.140831. Epub 2022 Aug 5.
Biochim Biophys Acta Proteins Proteom. 2022.
PMID: 35934298
Free PMC article.
A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer.
Jermusyk A, Zhong J, Connelly KE, Gordon N, Perera S, Abdolalizadeh E, Zhang T, O'Brien A, Hoskins JW, Collins I, Eiser D, Yuan C; PanScan Consortium; PanC4 Consortium; Risch HA, Jacobs EJ, Li D, Du M, Stolzenberg-Solomon RZ, Klein AP, Smith JP, Wolpin BM, Chanock SJ, Shi J, Petersen GM, Westlake CJ, Amundadottir LT.
Jermusyk A, et al.
Am J Hum Genet. 2021 Oct 7;108(10):1852-1865. doi: 10.1016/j.ajhg.2021.09.002. Epub 2021 Sep 23.
Am J Hum Genet. 2021.
PMID: 34559995
Free PMC article.
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Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis.
Seltsam K, Pentner C, Weigl F, Sutedjo S, Zimmer C, Beer S, Bugert P, Ewers M, Ruffert C, Michl P, Laumen H, Witt H, Rosendahl J.
Seltsam K, et al.
Pancreatology. 2020 Dec;20(8):1598-1603. doi: 10.1016/j.pan.2020.09.017. Epub 2020 Sep 29.
Pancreatology. 2020.
PMID: 33036922
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Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.
Rosendahl J, Kirsten H, Hegyi E, Kovacs P, Weiss FU, Laumen H, Lichtner P, Ruffert C, Chen JM, Masson E, Beer S, Zimmer C, Seltsam K, Algül H, Bühler F, Bruno MJ, Bugert P, Burkhardt R, Cavestro GM, Cichoz-Lach H, Farré A, Frank J, Gambaro G, Gimpfl S, Grallert H, Griesmann H, Grützmann R, Hellerbrand C, Hegyi P, Hollenbach M, Iordache S, Jurkowska G, Keim V, Kiefer F, Krug S, Landt O, Leo MD, Lerch MM, Lévy P, Löffler M, Löhr M, Ludwig M, Macek M, Malats N, Malecka-Panas E, Malerba G, Mann K, Mayerle J, Mohr S, Te Morsche RHM, Motyka M, Mueller S, Müller T, Nöthen MM, Pedrazzoli S, Pereira SP, Peters A, Pfützer R, Real FX, Rebours V, Ridinger M, Rietschel M, Rösmann E, Saftoiu A, Schneider A, Schulz HU, Soranzo N, Soyka M, Simon P, Skipworth J, Stickel F, Strauch K, Stumvoll M, Testoni PA, Tönjes A, Werner L, Werner J, Wodarz N, Ziegler M, Masamune A, Mössner J, Férec C, Michl P, P H Drenth J, Witt H, Scholz M, Sahin-Tóth M; all members of the PanEuropean Working group on ACP.
Rosendahl J, et al.
Gut. 2018 Oct;67(10):1855-1863. doi: 10.1136/gutjnl-2017-314454. Epub 2017 Jul 28.
Gut. 2018.
PMID: 28754779
Free PMC article.
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