Phagocytes in ischemia injury

K A Youker; H H Birdsall; N G Frangogiannis; A G Kumar; M L Lindsey; C M Ballantyne; C W Smith; R D Rossen; M L Entman

doi:10.1111/j.1749-6632.1997.tb46252.x

Phagocytes in ischemia injury

Ann N Y Acad Sci. 1997 Dec 15:832:243-65. doi: 10.1111/j.1749-6632.1997.tb46252.x.

Authors

K A Youker¹, H H Birdsall, N G Frangogiannis, A G Kumar, M L Lindsey, C M Ballantyne, C W Smith, R D Rossen, M L Entman

Affiliation

¹ Methodist Hospital, DeBakey Heart Center, Department of Medicine, Philadelphia, Pennsylvania, USA.

PMID: 9704052
DOI: 10.1111/j.1749-6632.1997.tb46252.x

Abstract

We are now developing the means to evaluate components of this inflammatory response that may facilitate healing. A key event in the change in the inflammatory response is the development of a cytokine cascade that promotes phenotypic changes in the infiltrating leukocytes, which endow them with the ability to promote fibroblast proliferation and collagen deposition, the hallmarks of healing.

MeSH terms

Animals
Chemotaxis, Leukocyte*
Coronary Circulation / physiology*
Dogs
Female
Flow Cytometry
Histamine Release
Leukocytes, Mononuclear / physiology
Lymph / immunology
Male
Monocytes / physiology
Myocardial Ischemia / blood
Myocardial Ischemia / immunology
Myocardial Ischemia / physiopathology*
Myocardial Reperfusion
Myocardium / metabolism
Phagocytes / physiology*
Tumor Necrosis Factor-alpha / biosynthesis

Substances

Tumor Necrosis Factor-alpha