Abstract
We report three patients who developed severe supraglottic airway obstruction due to Epstein-Barr virus lymphoproliferative disease following allogeneic bone marrow transplantation. In addition to enlarged pharyngeal lymphoid tissue seen in all three patients, two had supraglottic airway narrowing and two developed pulmonary lymphoproliferative disease. They were treated with unmanipulated T cells or EBV-specific cytotoxic T lymphocytes. Life-threatening upper airway obstruction is a radiologically detectable complication of allogeneic bone marrow transplantation in children.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adolescent
-
Airway Obstruction / etiology*
-
Bone Marrow Transplantation / adverse effects*
-
Bone Marrow Transplantation / immunology
-
Child
-
Child, Preschool
-
Female
-
Herpesviridae Infections / diagnostic imaging
-
Herpesviridae Infections / etiology*
-
Herpesviridae Infections / pathology
-
Herpesviridae Infections / therapy
-
Herpesvirus 4, Human* / immunology
-
Humans
-
Immunotherapy, Adoptive
-
Lung Diseases / diagnostic imaging
-
Lung Diseases / etiology*
-
Lung Diseases / pathology
-
Lymphocyte Depletion / adverse effects
-
Lymphoproliferative Disorders / diagnostic imaging
-
Lymphoproliferative Disorders / etiology*
-
Lymphoproliferative Disorders / pathology
-
Lymphoproliferative Disorders / therapy
-
Male
-
Radiography
-
T-Lymphocytes, Cytotoxic / immunology
-
T-Lymphocytes, Cytotoxic / transplantation