Methacrylonitrile induced oxidative stress in rat liver

Indian J Biochem Biophys. 1997 Dec;34(6):540-2.

Abstract

MeAN administration (40mg/kg body wt/day (i.e. 1/5 of LD50) resulted in increased levels of lipid peroxidation products, conjugated dienes and lipofuscin-like substances in rat liver. Significant decrease in GSH and a decreased activity of hepatic SOD, CAT and GPx were observed. There was also an increase in glutathione S-transferase and G6PD activities, decreased plasma ceruloplasmin and vitamin C implying oxidative stress caused by MeAN.

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Glutathione / metabolism
  • Lipid Peroxidation / drug effects
  • Lipofuscin / metabolism
  • Liver / drug effects*
  • Liver / metabolism*
  • Male
  • Methacrylates / toxicity*
  • Nitriles / toxicity*
  • Oxidative Stress / drug effects*
  • Rats
  • Rats, Wistar

Substances

  • Antioxidants
  • Lipofuscin
  • Methacrylates
  • Nitriles
  • methacrylonitrile
  • Glutathione